Association of HLA-A*02:06 and HLA-DRB1*04:05 with clinical subtypes of juvenile idiopathic arthritis
نویسندگان
چکیده
منابع مشابه
Hla and Juvenile Idiopathic Arthritis: an Overview
Juvenile Idiopathic Arthritis (JIA) is an umbrella term referring to a group of disorders characterized by chronic arthritis and is the most common chronic rheumatic illness . Although the exact etiology of JIA remains unclear, it seems to be a complex genetic trait involving the effects of multiple genes related to immunity and inflammation. This review aims to throw light on the association b...
متن کاملHLA B27 association in children with juvenile idiopathic arthritis: a clinical study of 72 patients
Current studies of HLA-associations in juvenile idiopathic arthritis (JIA) are directed at detection of the hallmarks of the disease, which may significantly improve the diagnostics for JIA. The purpose of this study was to determine the incidence of HLA B27 in children with JIA in Ukraine and to evaluate the natural history of the disease in HLA B27-positive patients. In this study, seventy-tw...
متن کاملProtective role of HLA-DRB1*11 against juvenile idiopathic arthritis living in North Eastern Iran
Objective(s): Juvenile idiopathic arthritis (JIA) is one of the most common chronic rheumatic diseases in children. The complex nature of this immune-mediated disease owes itself to several predisposing genes and environmental factors affecting its pathogenesis. Conducted in Iran, this study was originally intended to investigate every possible association between HLA DRB1 alleles and a suscept...
متن کاملHLA-G and HLA-E in patients with juvenile idiopathic arthritis.
OBJECTIVE To investigate the expression and release of HLA-G and HLA-E in JIA. METHODS Soluble (s)HLA-G and HLA-E were measured in sera from 58 JIA patients and 54 healthy donors. Surface expression of HLA-G, HLA-E and immunoglobulin-like transcript (ILT)2 and ILT4, two receptors for HLA-G, was assessed on T, B cells and monocytes from peripheral blood (PB) and SF of 12 JIA patients and from ...
متن کاملSequence Feature Variant Type (SFVT) Analysis of the HLA Genetic Association in Juvenile Idiopathic Arthritis
The immune response HLA class II DRB1 gene provides the major genetic contribution to Juvenile Idiopathic Arthritis (JIA), with a hierarchy of predisposing through intermediate to protective effects. With JIA, and the many other HLA associated diseases, it is difficult to identify the combinations of biologically relevant amino acid (AA) residues directly involved in disease due to the high lev...
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ژورنال
عنوان ژورنال: Journal of Human Genetics
سال: 2010
ISSN: 1434-5161,1435-232X
DOI: 10.1038/jhg.2010.159